topPTM:ADRB2

Beta-2 adrenergic receptor

Uniprot/Swiss-prot ID ADRB2_HUMAN

Protein name Beta-2 adrenergic receptor

Gene name Name: ADRB2
Synonyms: ADRB2R, B2AR

Organism Homo sapiens (Human).

Taxonomic lineage Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo.

Function Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.

PTM Phosphothreonine
Phosphotyrosine
Phosphoserine
N-palmitoyl cysteine
S-palmitoyl cysteine
N-linked (GlcNAc...)

Topology Preview

Localization Cell membrane; Multi-pass membrane protein. Note=Colocalizes with VHL at the cell membrane.

Gene Ontology(GO) C:apical plasma membrane
C:endosome
C:integral to plasma membrane
C:lysosome
C:nucleus
C:receptor complex
F:beta2-adrenergic receptor activity
F:norepinephrine binding
F:potassium channel regulator activity
F:protein homodimerization activity
P:activation of adenylate cyclase activity
P:activation of transmembrane receptor protein tyrosine kinase activity
P:adenylate cyclase-activating G-protein coupled receptor signaling pathway
P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway
P:bone resorption
P:brown fat cell differentiation
P:desensitization of G-protein coupled receptor protein signaling pathway by arrestin
P:diet induced thermogenesis
P:endosome to lysosome transport
P:heat generation
P:negative regulation of multicellular organism growth
P:negative regulation of smooth muscle contraction
P:positive regulation of bone mineralization
P:positive regulation of MAPK cascade
P:positive regulation of protein ubiquitination
P:positive regulation of transcription from RNA polymerase II promoter
P:receptor-mediated endocytosis
P:regulation of sodium ion transport
P:response to cold
P:vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure

InterPro IPR000332: Adrgc_rcpt_B2
IPR002233: Adrnrgc_rcpt
IPR000276: GPCR_Rhodpsn
IPR017452: GPCR_Rhodpsn_7TM

PDB

Entry	Method	Å	Chain	Positions	3D
1GQ4	X-ray	1.90	A	409-413
2R4R	X-ray	3.40	A	1-365
2R4S	X-ray	3.40	A	24-365
2RH1	X-ray	2.40	A	1-365
3D4S	X-ray	2.80	A	1-348
3KJ6	X-ray	3.40	A	2-365
3NY8	X-ray	2.84	A	1-348
3NY9	X-ray	2.84	A	1-348
3NYA	X-ray	3.16	A	1-348
3P0G	X-ray	3.50	A	1-365
3PDS	X-ray	3.50	A	25-348
3SN6	X-ray	3.20	R	29-365
4GBR	X-ray	3.99	A	29-365

Sequence

Length: 413

MGQPGNGSAF LLAPNGSHAP DHDVTQERDE VWVVGMGIVM SLIVLAIVFG NVLVITAIAK FERLQTVTNY FITSLACADL VMGLAVVPFG AAHILMKMWT FGNFWCEFWT SIDVLCVTAS IETLCVIAVD RYFAITSPFK YQSLLTKNKA RVIILMVWIV SGLTSFLPIQ MHWYRATHQE AINCYANETC CDFFTNQAYA IASSIVSFYV PLVIMVFVYS RVFQEAKRQL QKIDKSEGRF HVQNLSQVEQ DGRTGHGLRR SSKFCLKEHK ALKTLGIIMG TFTLCWLPFF IVNIVHVIQD NLIRKEVYIL LNWIGYVNSG FNPLIYCRSP DFRIAFQELL CLRRSSLKAY GNGYSSNGNT GEQSGYHVEQ EKENKLLCED LPGTEDFVGH QGTVPSDNID SQGRNCSTND SLL

Kegg Pathway hsa04020:Calcium signaling pathway - Homo sapiens (human)
hsa04080:Neuroactive ligand-receptor interaction - Homo sapiens (human)
hsa04144:Endocytosis - Homo sapiens (human)
hsa04970:Salivary secretion - Homo sapiens (human)

Disease Reference

KEGG disease	H00079: Asthma
Omim	109690: BETA-2-ADRENERGIC RECEPTOR; ADRB2 ;;BETA-ADRENERGIC RECEPTOR; ADRBR;; BETA-2-ADRENOCEPTOR; B 600807: ASTHMA, SUSCEPTIBILITY TO ;;ASTHMA, BRONCHIAL;; ASTHMA-RELATED TRAITS, SUSCEPTIBILITY TO AST 601665: OBESITY LEANNESS, INCLUDED

Drug Reference

Kegg drug

D00076: Noradrenaline (JP16); Norepinephrine (INN); Nor adrenalin (TN)
D00095: Adrenaline (JP16); Epinephrine (USP/INN); Adrenalin (TN); Auvi-q (TN); Epipen (TN)
D00124: Ephedrine (USP); Ephedrine (TN)
D00255: Carvedilol (JAN/USAN/INN); Artist (TN); Coreg (TN)
D00378: Timolol (USAN); Timolol hemihydrate; Betimol (TN)
D00432: Nadolol (JP16/USP/INN); Corgard (TN)
D00483: Propranolol hydrochloride (JP16/USP); Inderal (TN); Innopran XL (TN)
D00485: Pseudoephedrine hydrochloride (USP); Sudafed (TN)
D00513: Pindolol (JP16/USP/INN); Blocklin-L (TN); Carvisken (TN); Visken (TN)
D00599: Carteolol hydrochloride (JP16/USP); Cartrol (TN); Ocupress (TN)
D00600: Labetalol hydrochloride (JP16/USP); Normodyne (TN); Trandate (TN)
D00602: Penbutolol sulfate (JP16/USP); Levatol (TN)
D00603: Timolol maleate (JP16/USP); Blocadren (TN); Istalol (TN); Timoptic (TN)
D00683: Salbutamol sulfate (JP16); Albuterol sulfate (USP); Accuneb (TN); Proventil (TN); Ventolin (TN)
D00684: Bitolterol mesilate (JAN); Bitolterol mesylate (USAN); Tornalate (TN)
D00685: Orciprenaline sulfate (JP16); Metaproterenol sulfate (USP); Alupent (TN)
D00686: Pirbuterol acetate (USAN); Maxair (TN)
D00687: Salmeterol xinafoate (JAN/USAN); Serevent (TN)
D00688: Terbutaline sulfate (JP16/USP); Brethine (TN)
D00996: Epinephrine hydrochloride (JAN); Adrenalin chloride (TN)
D01017: Dipivefrin hydrochloride (JAN/USP); Propine (TN)
D01025: Levobunolol hydrochloride (JAN/USP); Betagan (TN)
D01026: Sotalol hydrochloride (JAN/USP); Betapace (TN); Sorine (TN)
D01182: Alprenolol hydrochloride (JP16/USAN); Regletin (TN)
D01263: Ritodrine hydrochloride (JP16/USP); Yutopar (TN)
D01349: Pirbuterol hydrochloride (JAN/USAN)
D01360: Clenbuterol hydrochloride (JAN/USP); Spiropent (TN)
D01362: Tulobuterol hydrochloride (JP16); Hokunalin (TN); Respacal (TN)
D01373: Formoterol fumarate (USAN); Foradil (TN)
D01386: Ephedrine hydrochloride (JP16/USP); Ephedrine hydrochloride (TN)
D01390: dl-Isoprenaline hydrochloride (JAN); Isoproterenol hydrochloride (USP); Isuprel (TN); Proternol-S (T
D01428: Fenoterol hydrobromide (JAN); Berotec (TN)
D01444: Bunitrolol hydrochloride (JAN); Betrilol (TN)
D01454: Bupranolol hydrochloride (JP16)
D01469: Amosulalol hydrochloride (JP16); Lowgan (TN)
D01504: Bufetolol hydrochloride (JP16); Adobiol (TN)
D01512: Befunolol hydrochloride (JAN); Bentos (TN)
D01543: Nylidrin hydrochloride (JAN); Buphenine hydrochloride; Arlidin (TN)
D01589: Mabuterol hydrochloride (JAN); Broncholin (TN)
D01635: Methoxyphenamine hydrochloride (JAN); Phenamine (TN)
D01691: Nipradilol (JAN/INN); Hypadil (TN)
D01748: Isoxsuprine hydrochloride (JP16/USP); Duvadilan (TN)
D01794: Bopindolol malonate (JAN); Sandonorm (TN)
D01795: Tilisolol hydrochloride (JAN); Selecal (TN)
D01806: Oxprenolol hydrochloride (JP16/USP); Okuspurecol (TN)
D01830: Arotinolol hydrochloride (JP16); Almarl (TN)
D01835: Clorprenaline hydrochloride (JAN/USAN)
D01952: L-Methylephedrine hydrochloride (JAN)
D01958: Indenolol hydrochloride (JP16)
D01978: Trimetoquinol hydrochloride; Tretoquinol; Inolin (TN)
D02066: Isoprenaline sulfate (JAN); Isoproterenol sulfate (USP); Luf-Iso (TN); Medihaler-Iso (TN)
D02081: Metipranolol hydrochloride; Optipranolol (TN)
D02093: Isoetharine hydrochloride (USP); BETA-2 (TN)
D02109: dl-Methylephedrine hydrochloride (JP16); Methy-F (TN)
D02147: Albuterol (USP); Salbutamol; Proventil (TN)
D02149: Epinephrine bitartrate (JAN/USP); Asmatane mist (TN); Medihaler-epi (TN)
D02150: l-Isoprenaline hydrochloride (JP16); Proternol-L (TN)
D02151: Tulobuterol (JAN/INN); Atenos (TN); Hokunalin (TN)
D02281: Levalbuterol hydrochloride (USAN); Xopenex (TN)
D02349: Dipivefrin (USAN); Dipivefrine (INN)
D02359: Ritodrine (USAN/INN)
D02374: Metipranolol (USAN/INN)
D02389: Primidolol (USAN/INN)
D02396: Hexoprenaline sulfate (USAN); Delaprem (TN)
D02404: Procaterol hydrochloride (USAN); Pro-Air (TN)
D02702: Talibegron hydrochloride (USAN)
D02765: Adaprolol maleate (USAN)
D02834: Alprenoxime hydrochloride (USAN)
D02976: Arbutamine hydrochloride (USAN); Genesa (TN)
D02981: Arformoterol tartrate (USAN); Brovana (TN)
D03170: Bucindolol hydrochloride (USAN)
D03177: Bunolol hydrochloride (USAN)
D03198: Butoxamine hydrochloride (USAN)
D03402: Carbuterol hydrochloride (USAN)
D03415: Carvedilol phosphate hydrate (JAN); Carvedilol phosphate (USAN); Coreg CR (TN)
D03449: Cetamolol hydrochloride (USAN)
D03490: Cicloprolol hydrochloride (USAN)
D03502: Cimaterol (USAN/INN)
D03587: Colterol mesylate (USAN)
D03729: Dexpropranolol hydrochloride (USAN)
D03759: Diacetolol hydrochloride (USAN)
D03891: Dopexamine (USAN/INN)
D04018: Ephedrine sulfate (USP); Isofedrol (TN)
D04157: Fenoterol (USAN/INN)
D04190: Flestolol sulfate (USAN)
D04625: Isoetharine (USP); Isoetarine (INN)
D04626: Isoetharine mesylate (USP); Bronkometer (TN)
D04701: Levalbuterol sulfate (USAN)
D04703: Levalbuterol tartrate (USAN); Xopenex HFA (TN)
D04888: Medroxalol (USAN/INN)
D04889: Medroxalol hydrochloride (USAN)
D04954: Metaproterenol polistirex (USAN)
D05037: Trimetoquinol hydrochloride hydrate (JP16); Tretoquinol hydrate; Caluyon (TN)
D05206: Norepinephrine bitartrate (USP); Levophed (TN)
D05277: Formoterol fumarate hydrate (JP16); Formoterol fumarate dihydrate; Atock (TN); Foradil (TN)
D05345: Pamatolol sulfate (USAN)
D05366: Procaterol hydrochloride hydrate (JP16); Meptin (TN)
D05476: Picumeterol fumarate (USAN)
D05648: Pseudoephedrine polistirex (USAN); Pseudo-12 (TN)
D05649: Pseudoephedrine sulfate (USP); Afrinol (TN)
D05691: Ractopamine hydrochloride (USAN)
D05718: Reproterol hydrochloride (USAN)
D05730: Rimiterol hydrobromide (USAN)
D05792: Salmeterol (USAN/INN)
D05832: Sibenadet hydrochloride (USAN); Viozan (TN)
D05902: Soterenol hydrochloride (USAN)
D06374: Zinterol hydrochloride (USAN)
D07156: Alprenolol (INN)
D07181: Mepindolol (INN)
D07182: Tertatolol (INN)
D07183: Cloranolol (INN)
D07377: Bambuterol (INN)
D07451: Amosulalol (INN)
D07463: Arformoterol (INN)
D07465: Arotinolol (INN)
D07489: Bambuterol hydrochloride; Bambec (TN)
D07534: Bitolterol (INN)
D07537: Bopindolol (INN); Sandonorm (TN)
D07551: Buphenine (INN)
D07590: Bupranolol (INN)
D07608: Carazolol (INN); Conducton (TN); Suacron [veterinary] (TN)
D07624: Carteolol (INN)
D07713: Clenbuterol (INN); Contraspasmin (TN); Planipart [veterinary] (TN)
D07990: Formoterol (INN); Oxis (TN)
D08039: Hexoprenaline (INN); Ipradol (TN)
D08074: Penbutolol (INN)
D08078: Indenolol (INN)
D08090: Isoprenaline (INN)
D08092: Isoxsuprine (INN); Dilator (TN)
D08093: Isoxsuprine lactate; Duphaspasmin [veterinary] (TN)
D08106: Labetalol (INN)
D08115: Levobunolol (INN)
D08124: Levosalbutamol (INN)
D08206: Methylephedrine (BAN)
D08284: Norepinephrine hydrochoride; (-)-Noradrenaline hydrochloride; Arterenol (TN)
D08300: Orciprenaline (INN); Metaproterenol
D08318: Oxprenolol (INN); Oxprenolol (TN)
D08387: Pirbuterol (INN)
D08424: Procaterol (INN); Meptin (TN)
D08443: Propranolol (INN); Propranolol (TN)
D08449: Pseudoephedrine (INN); Neodurasina (TN); Acunaso (TN)
D08474: Reproterol (INN)
D08525: Sotalol (INN); Darob mite (TN)
D08570: Terbutaline (INN); Asthmasian (TN)
D08572: Tertatolol hydrochloride; Artex (TN)
D08598: Tilisolol (INN)
D08600: Timolol (INN); Timolol (TN); Betimol (TN)
D08629: Tretoquinol (INN)
D08945: Milveterol hydrochloride (USAN)
D09318: Indacaterol (USAN/INN)
D09319: Indacaterol maleate (JAN/USAN); Arcapta neohaler (TN)
D09696: Vilanterol (USAN)
D09697: Vilanterol trifenatate (JAN/USAN)
D09794: Norepinephrine hydrochloride (JAN); (+/-)-Noradrenaline hydrochloride
D09842: dl-Methylephedrine saccharinate (JAN)
D09843: Beradilol monoethyl maleate (JAN); TZC-5665
D10020: Olodaterol hydrochloride (JAN/USAN)
D10145: Olodaterol (USAN/INN)
D10219: abediterol (USAN/INN)
D10220: Abediterol napadisylate (USAN)

DrugBank

DB00866: Alprenolol
DB01274: Arformoterol
DB01408: Bambuterol
DB00612: Bisoprolol
DB00901: Bitolterol
DB01158: Bretylium
DB00521: Carteolol
DB01136: Carvedilol
DB01407: Clenbuterol
DB01151: Desipramine
DB00668: Epinephrine
DB01288: Fenoterol
DB00983: Formoterol
DB01064: Isoproterenol
DB00598: Labetalol
DB01210: Levobunolol
DB01214: Metipranolol
DB01203: Nadolol
DB00368: Norepinephrine
DB00816: Orciprenaline
DB01580: Oxprenolol
DB01359: Penbutolol
DB00960: Pindolol
DB01291: Pirbuterol
DB01366: Procaterol
DB00571: Propranolol
DB00852: Pseudoephedrine
DB00867: Ritodrine
DB01001: Salbutamol
DB00938: Salmeterol
DB00871: Terbutaline
DB00373: Timolol

Start	Sequence	End	Region	Literature
1	`MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVV`	34	Extracellular
35	`GMGIVMSLIVLAIVFGNVLVITAI`	58	Transmembrane(Helical)	-
59	`AKFERLQTVTNYF`	71	Cytoplasmic
72	`ITSLACADLVMGLAVVPFGAAHIL`	95	Transmembrane(Helical)	-
96	`MKMWTFGNFWC`	106	Extracellular
107	`EFWTSIDVLCVTASIETLCVIAV`	129	Transmembrane(Helical)	-
130	`DRYFAITSPFKYQSLLTKNKA`	150	Cytoplasmic
151	`RVIILMVWIVSGLTSFLPIQMHWY`	174	Transmembrane(Helical)	-
175	`RATHQEAINCYANETCCDFFTN`	196	Extracellular
197	`QAYAIASSIVSFYVPLVIMVFVYS`	220	Transmembrane(Helical)	-
221	`RVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKT`	274	Cytoplasmic
275	`LGIIMGTFTLCWLPFFIVNIVHVI`	298	Transmembrane(Helical)	-
299	`QDNLIRK`	305	Extracellular
306	`EVYILLNWIGYVNSGFNPLIYCRS`	329	Transmembrane(Helical)	-
330	`PDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL`	413	Cytoplasmic

PTM	Site	Enzyme	Literature	Resource	View 3D
Phosphothreonine	68	-		Phosphositeplus	2R4R_A; 2R4S_A; 2RH1_A; 3D4S_A; 3KJ6_A; 3NY8_A; 3NY9_A; 3NYA_A; 3P0G_A; 3PDS_A; 3SN6_R; 4GBR_A;
Phosphotyrosine	132	INSR		HPRD / Phosphositeplus / PhosphoELM	2R4R_A; 2R4S_A; 2RH1_A; 3D4S_A; 3KJ6_A; 3NY8_A; 3NY9_A; 3NYA_A; 3P0G_A; 3PDS_A; 3SN6_R; 4GBR_A;
Phosphotyrosine	141	INSR		HPRD / Phosphositeplus / Uniprot / PhosphoELM	2R4R_A; 2R4S_A; 2RH1_A; 3D4S_A; 3KJ6_A; 3NY8_A; 3NY9_A; 3NYA_A; 3P0G_A; 3PDS_A; 3SN6_R; 4GBR_A;
Phosphotyrosine	219	-		Phosphositeplus	2R4R_A; 2R4S_A; 2RH1_A; 3D4S_A; 3KJ6_A; 3NY8_A; 3NY9_A; 3NYA_A; 3P0G_A; 3PDS_A; 3SN6_R; 4GBR_A;
Phosphoserine	246	-		HPRD / PhosphoELM / Phosphositeplus / Uniprot	2R4R_A; 2R4S_A; 2RH1_A; 3D4S_A; 3KJ6_A; 3NY8_A; 3NY9_A; 3NYA_A; 3P0G_A; 3PDS_A; 3SN6_R; 4GBR_A;
Phosphoserine	261	PRKCD		HPRD / Phosphositeplus	2R4R_A; 2R4S_A; 2RH1_A; 3D4S_A; 3KJ6_A; 3NY8_A; 3NY9_A; 3NYA_A; 3P0G_A; 3PDS_A; 3SN6_R; 4GBR_A;
Phosphoserine	262	PRKCD		HPRD / Phosphositeplus / PhosphoELM	2R4R_A; 2R4S_A; 2RH1_A; 3D4S_A; 3KJ6_A; 3NY8_A; 3NY9_A; 3NYA_A; 3P0G_A; 3PDS_A; 3SN6_R; 4GBR_A;
Phosphotyrosine	326	-		HPRD / PhosphoELM / Phosphositeplus	2R4R_A; 2R4S_A; 2RH1_A; 3D4S_A; 3KJ6_A; 3NY8_A; 3NY9_A; 3NYA_A; 3P0G_A; 3PDS_A; 3SN6_R; 4GBR_A;
N-palmitoyl cysteine	341	-		HPRD	2R4R_A; 2R4S_A; 2RH1_A; 3D4S_A; 3KJ6_A; 3NY8_A; 3NY9_A; 3NYA_A; 3P0G_A; 3PDS_A; 3SN6_R; 4GBR_A;
S-palmitoyl cysteine	341	-		Uniprot	2R4R_A; 2R4S_A; 2RH1_A; 3D4S_A; 3KJ6_A; 3NY8_A; 3NY9_A; 3NYA_A; 3P0G_A; 3PDS_A; 3SN6_R; 4GBR_A;
Phosphoserine	345	PRKCD		HPRD / Phosphositeplus / Uniprot / PhosphoELM	2R4R_A; 2R4S_A; 2RH1_A; 3D4S_A; 3KJ6_A; 3NY8_A; 3NY9_A; 3NYA_A; 3P0G_A; 3PDS_A; 3SN6_R; 4GBR_A;
Phosphoserine	346	PRKCD		HPRD / Phosphositeplus / Uniprot / PhosphoELM	2R4R_A; 2R4S_A; 2RH1_A; 3D4S_A; 3KJ6_A; 3NY8_A; 3NY9_A; 3NYA_A; 3P0G_A; 3PDS_A; 3SN6_R; 4GBR_A;
Phosphotyrosine	350	INSR		HPRD / Phosphositeplus	2R4R_A; 2R4S_A; 2RH1_A; 3KJ6_A; 3P0G_A; 3SN6_R; 4GBR_A;
Phosphotyrosine	354	INSR		HPRD / Phosphositeplus	2R4R_A; 2R4S_A; 2RH1_A; 3KJ6_A; 3P0G_A; 3SN6_R; 4GBR_A;
Phosphoserine	355	-		Phosphositeplus / PhosphoELM	2R4R_A; 2R4S_A; 2RH1_A; 3KJ6_A; 3P0G_A; 3SN6_R; 4GBR_A;
Phosphoserine	356	-		Phosphositeplus / PhosphoELM	2R4R_A; 2R4S_A; 2RH1_A; 3KJ6_A; 3P0G_A; 3SN6_R; 4GBR_A;
Phosphothreonine	360	-		Phosphositeplus	2R4R_A; 2R4S_A; 2RH1_A; 3KJ6_A; 3P0G_A; 3SN6_R; 4GBR_A;
Phosphoserine	364	-		HPRD / Phosphositeplus	2R4R_A; 2R4S_A; 2RH1_A; 3KJ6_A; 3P0G_A; 3SN6_R; 4GBR_A;
4-hydroxyproline	382	-		Uniprot
Phosphothreonine	384	GRK5		HPRD / Phosphositeplus / PhosphoELM
Phosphothreonine	393	GRK5		HPRD / Phosphositeplus / PhosphoELM
4-hydroxyproline	395	-		Uniprot
Phosphoserine	396	GRK5		HPRD / Phosphositeplus / PhosphoELM
Phosphoserine	401	GRK5		HPRD / Phosphositeplus / PhosphoELM
Phosphoserine	407	GRK5		HPRD / Phosphositeplus / PhosphoELM
Phosphothreonine	408	-		Phosphositeplus
Phosphoserine	411	GRK5		HPRD / Phosphositeplus / PhosphoELM	1GQ4_A;

PTM	Site	Enzyme	Note.	Resource	View 3D
N-linked (GlcNAc...)	6	-	Probable	Uniprot	2R4R_A; 2RH1_A; 3D4S_A; 3KJ6_A; 3NY8_A; 3NY9_A; 3NYA_A; 3P0G_A;
N-linked (GlcNAc...)	15	-	Probable	Uniprot	2R4R_A; 2RH1_A; 3D4S_A; 3KJ6_A; 3NY8_A; 3NY9_A; 3NYA_A; 3P0G_A;