topPTM:CCR5

C-C chemokine receptor type 5

Uniprot/Swiss-prot ID CCR5_HUMAN

Protein name C-C chemokine receptor type 5

Gene name Name: CCR5
Synonyms: CMKBR5

Organism Homo sapiens (Human).

Taxonomic lineage Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo.

Function Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.

PTM Sulfotyrosine
O-linked (GalNAc...)
N-palmitoyl cysteine
S-palmitoyl cysteine
Phosphoserine

Topology Preview

Localization Cell membrane; Multi-pass membrane protein.

Gene Ontology(GO) C:endosome
C:external side of plasma membrane
C:integral to plasma membrane
F:actin binding
F:C-C chemokine receptor activity
F:coreceptor activity
F:phosphatidylinositol phospholipase C activity
P:calcium-mediated signaling
P:cell-cell signaling
P:cellular defense response
P:cellular response to lipopolysaccharide
P:dendritic cell chemotaxis
P:entry into host cell
P:immune response
P:inflammatory response
P:MAPK cascade
P:negative regulation of cAMP biosynthetic process
P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
P:response to cholesterol
P:viral reproductive process
P:virus-host interaction

InterPro IPR002240: Chemokine_CCR5
IPR000355: Chemokine_rcpt
IPR000276: GPCR_Rhodpsn
IPR017452: GPCR_Rhodpsn_7TM

PDB

Entry	Method	Å	Chain	Positions	3D
1ND8	Model	-	A	1-352
1NE0	Model	-	A	1-352
1OPN	Model	-	A	1-352
1OPT	Model	-	A	1-352
1OPW	Model	-	A	1-352
2L87	NMR	-	A	1-27
2RLL	NMR	-	A	7-15
2RRS	NMR	-	A	157-174

Sequence

Length: 352

MDYQVSSPIY DINYYTSEPC QKINVKQIAA RLLPPLYSLV FIFGFVGNML VILILINCKR LKSMTDIYLL NLAISDLFFL LTVPFWAHYA AAQWDFGNTM CQLLTGLYFI GFFSGIFFII LLTIDRYLAV VHAVFALKAR TVTFGVVTSV ITWVVAVFAS LPGIIFTRSQ KEGLHYTCSS HFPYSQYQFW KNFQTLKIVI LGLVLPLLVM VICYSGILKT LLRCRNEKKR HRAVRLIFTI MIVYFLFWAP YNIVLLLNTF QEFFGLNNCS SSNRLDQAMQ VTETLGMTHC CINPIIYAFV GEKFRNYLLV FFQKHIAKRF CKCCSIFQQE APERASSVYT RSTGEQEISV GL

Kegg Pathway hsa04060:Cytokine-cytokine receptor interaction - Homo sapiens (human)
hsa04062:Chemokine signaling pathway - Homo sapiens (human)
hsa04144:Endocytosis - Homo sapiens (human)
hsa05145:Toxoplasmosis - Homo sapiens (human)
hsa05203:Viral carcinogenesis - Homo sapiens (human)

Disease Reference

KEGG disease	-
Omim	601373: CHEMOKINE, CC MOTIF, RECEPTOR 5; CCR5 ;;CC CHEMOKINE RECEPTOR 5; CCCKR5;; CMKBR5;; CKR5 609532: HEPATITIS C VIRUS, SUSCEPTIBILITY TO ;;HCV, SUSCEPTIBILITY TO HEPATITIS C VIRUS, RESISTANCE 610379: WEST NILE VIRUS, SUSCEPTIBILITY TO ;;WNV, SUSCEPTIBILITY TO 612522: DIABETES MELLITUS, INSULIN-DEPENDENT, 22; IDDM22

Drug Reference

Kegg drug	D03210: Ancriviroc (USAN/INN) D06297: Vicriviroc maleate (USAN) D06557: Aplaviroc hydrochloride (USAN) D06670: Maraviroc (JAN/INN); Selzentry (TN) D09878: Cenicriviroc (USAN/INN) D09879: Cenicriviroc mesylate (USAN)
DrugBank	DB04835: Maraviroc

Start	Sequence	End	Region	Literature
1	`MDYQVSSPIYDINYYTSEPCQKINVKQIAA`	30	Extracellular	Potential
31	`RLLPPLYSLVFIFGFVGNMLVILILINC`	58	Transmembrane(Helical)	Potential
59	`KRLKSMTDIY`	68	Cytoplasmic	Potential
69	`LLNLAISDLFFLLTVPFWAHY`	89	Transmembrane(Helical)	Potential
90	`AAAQWDFGNTMCQ`	102	Extracellular	Potential
103	`LLTGLYFIGFFSGIFFIILLTI`	124	Transmembrane(Helical)	Potential
125	`DRYLAVVHAVFALKART`	141	Cytoplasmic	Potential
142	`VTFGVVTSVITWVVAVFASLPGIIF`	166	Transmembrane(Helical)	Potential
167	`TRSQKEGLHYTCSSHFPYSQYQFWKNFQTLKI`	198	Extracellular	Potential
199	`VILGLVLPLLVMVICYSGIL`	218	Transmembrane(Helical)	Potential
219	`KTLLRCRNEKKRHRAVR`	235	Cytoplasmic	Potential
236	`LIFTIMIVYFLFWAPYNIVLLLNTF`	260	Transmembrane(Helical)	Potential
261	`QEFFGLNNCSSSNRLDQ`	277	Extracellular	Potential
278	`AMQVTETLGMTHCCINPIIYAFVG`	301	Transmembrane(Helical)	Potential
302	`EKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL`	352	Cytoplasmic	Potential

PTM	Site	Enzyme	Literature	Resource	View 3D
Sulfotyrosine	3	-		HPRD / Uniprot	1ND8_A; 1NE0_A; 1OPN_A; 1OPT_A; 1OPW_A; 2L87_A;
O-linked (GalNAc...)	6	-		HPRD / Uniprot	1ND8_A; 1NE0_A; 1OPN_A; 1OPT_A; 1OPW_A; 2L87_A;
Sulfotyrosine	10	-		HPRD / Uniprot	1ND8_A; 1NE0_A; 1OPN_A; 1OPT_A; 1OPW_A; 2L87_A; 2RLL_A;
Sulfotyrosine	14	-		HPRD / Uniprot	1ND8_A; 1NE0_A; 1OPN_A; 1OPT_A; 1OPW_A; 2L87_A; 2RLL_A;
Sulfotyrosine	15	-		HPRD	1ND8_A; 1NE0_A; 1OPN_A; 1OPT_A; 1OPW_A; 2L87_A; 2RLL_A;
N-palmitoyl cysteine	321	-		HPRD	1ND8_A; 1NE0_A; 1OPN_A; 1OPT_A; 1OPW_A;
S-palmitoyl cysteine	321	-		Uniprot	1ND8_A; 1NE0_A; 1OPN_A; 1OPT_A; 1OPW_A;
N-palmitoyl cysteine	323	-		HPRD	1ND8_A; 1NE0_A; 1OPN_A; 1OPT_A; 1OPW_A;
S-palmitoyl cysteine	323	-		Uniprot	1ND8_A; 1NE0_A; 1OPN_A; 1OPT_A; 1OPW_A;
N-palmitoyl cysteine	324	-		HPRD	1ND8_A; 1NE0_A; 1OPN_A; 1OPT_A; 1OPW_A;
S-palmitoyl cysteine	324	-		Uniprot	1ND8_A; 1NE0_A; 1OPN_A; 1OPT_A; 1OPW_A;
Phosphoserine	336	ADRBK2		HPRD / Phosphositeplus / Uniprot / PhosphoELM	1ND8_A; 1NE0_A; 1OPN_A; 1OPT_A; 1OPW_A;
Phosphoserine	337	ADRBK2		HPRD / Phosphositeplus / Uniprot / PhosphoELM	1ND8_A; 1NE0_A; 1OPN_A; 1OPT_A; 1OPW_A;
Phosphotyrosine	339	-		Phosphositeplus	1ND8_A; 1NE0_A; 1OPN_A; 1OPT_A; 1OPW_A;
Phosphoserine	342	ADRBK2		HPRD / Phosphositeplus / Uniprot / PhosphoELM	1ND8_A; 1NE0_A; 1OPN_A; 1OPT_A; 1OPW_A;
Phosphoserine	349	ADRBK2		HPRD / Phosphositeplus / Uniprot / PhosphoELM	1ND8_A; 1NE0_A; 1OPN_A; 1OPT_A; 1OPW_A;

PTM	Site	Enzyme	Note.	Resource	View 3D
O-linked (GalNAc...)	7	-	Probable	Uniprot	1ND8_A; 1NE0_A; 1OPN_A; 1OPT_A; 1OPW_A; 2L87_A; 2RLL_A;
O-linked (GalNAc...)	16	-	Potential	Uniprot	1ND8_A; 1NE0_A; 1OPN_A; 1OPT_A; 1OPW_A; 2L87_A;
O-linked (GalNAc...)	17	-	Potential	Uniprot	1ND8_A; 1NE0_A; 1OPN_A; 1OPT_A; 1OPW_A; 2L87_A;