Cystic fibrosis transmembrane conductance regulator

Uniprot/Swiss-prot ID CFTR_MOUSE
Protein name Cystic fibrosis transmembrane conductance regulator
Gene name Name: Cftr
Synonyms: Abcc7
Organism Mus musculus (Mouse).
Taxonomic lineage Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Sciurognathi > Muroidea > Muridae > Murinae > Mus > Mus.
Function Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1 (By similarity).
PTM N-linked (GlcNAc...)
S-palmitoyl cysteine
Phosphoserine
Phosphothreonine
Topology Preview
Localization Early endosome membrane; Multi-pass membrane protein (By similarity). Cell membrane (By similarity).
Gene Ontology(GO) C:apical plasma membrane
C:basolateral plasma membrane
C:chloride channel complex
C:cytoplasmic vesicle membrane
C:early endosome
C:early endosome membrane
C:endoplasmic reticulum Sec complex
C:microvillus
C:plasma membrane
F:ATP binding
F:bicarbonate transmembrane transporter activity
F:channel-conductance-controlling ATPase activity
F:chloride channel activity
F:chloride channel inhibitor activity
P:ATP catabolic process
P:cellular response to cAMP
P:cellular response to hormone stimulus
P:cholesterol biosynthetic process
P:cholesterol transport
P:intracellular pH elevation
P:iodide transport
P:lung development
P:membrane hyperpolarization
P:positive regulation of vasodilation
P:response to cytokine stimulus
P:response to drug
P:response to estrogen stimulus
P:response to peptide hormone stimulus
P:sperm capacitation
P:transepithelial chloride transport
P:vasodilation
P:water transport
InterPro IPR003593: AAA+_ATPase
IPR003439: ABC_transporter-like
IPR017871: ABC_transporter_CS
IPR017940: ABC_transporter_type1
IPR001140: ABC_transptr_TM_dom
IPR011527: ABC_transptrTM_dom_typ1
IPR005291: cAMP_cl_channel
IPR025837: CFTR_reg_dom
IPR009147: CysFib_conduc_TM
IPR027417: P-loop_NTPase
PDB
EntryMethodÅChainPositions3D
1Q3HX-ray2.50A/B/C/D389-673
1R0WX-ray2.20A/B/C/D389-673
1R0XX-ray2.20A/B/C/D389-673
1R0YX-ray2.55A/B/C/D389-673
1R0ZX-ray2.35A/B/C/D389-673
1R10X-ray3.00A/B389-673
1XF9X-ray2.70A/B/C/D389-670
1XFAX-ray3.10A/B389-670
3SI7X-ray2.25A/B/C/D389-673
Sequence
Length: 1476
MQKSPLEKAS FISKLFFSWT TPILRKGYRH HLELSDIYQA PSADSADHLS EKLEREWDRE QASKKNPQLI HALRRCFFWR FLFYGILLYL GEVTKAVQPV LLGRIIASYD PENKVERSIA IYLGIGLCLL FIVRTLLLHP AIFGLHRIGM QMRTAMFSLI YKKTLKLSSR VLDKISIGQL VSLLSNNLNK FDEGLALAHF IWIAPLQVTL LMGLLWDLLQ FSAFCGLGLL IILVIFQAIL GKMMVKYRDQ RAAKINERLV ITSEIIDNIY SVKAYCWESA MEKMIENLRE VELKMTRKAA YMRFFTSSAF FFSGFFVVFL SVLPYTVING IVLRKIFTTI SFCIVLRMSV TRQFPTAVQI WYDSFGMIRK IQDFLQKQEY KVLEYNLMTT GIIMENVTAF WEEGFGELLE KVQQSNGDRK HSSDENNVSF SHLCLVGNPV LKNINLNIEK GEMLAITGST GSGKTSLLML ILGELEASEG IIKHSGRVSF CSQFSWIMPG TIKENIIFGV SYDEYRYKSV VKACQLQQDI TKFAEQDNTV LGEGGVTLSG GQRARISLAR AVYKDADLYL LDSPFGYLDV FTEEQVFESC VCKLMANKTR ILVTSKMEHL RKADKILILH QGSSYFYGTF SELQSLRPDF SSKLMGYDTF DQFTEERRSS ILTETLRRFS VDDSSAPWSK PKQSFRQTGE VGEKRKNSIL NSFSSVRKIS IVQKTPLCID GESDDLQEKR LSLVPDSEQG EAALPRSNMI ATGPTFPGRR RQSVLDLMTF TPNSGSSNLQ RTRTSIRKIS LVPQISLNEV DVYSRRLSQD STLNITEEIN EEDLKECFLD DVIKIPPVTT WNTYLRYFTL HKGLLLVLIW CVLVFLVEVA ASLFVLWLLK NNPVNSGNNG TKISNSSYVV IITSTSFYYI FYIYVGVADT LLALSLFRGL PLVHTLITAS KILHRKMLHS ILHAPMSTIS KLKAGGILNR FSKDIAILDD FLPLTIFDFI QLVFIVIGAI IVVSALQPYI FLATVPGLVV FILLRAYFLH TAQQLKQLES EGRSPIFTHL VTSLKGLWTL RAFRRQTYFE TLFHKALNLH TANWFMYLAT LRWFQMRIDM IFVLFFIVVT FISILTTGEG EGTAGIILTL AMNIMSTLQW AVNSSIDTDS LMRSVSRVFK FIDIQTEESM YTQIIKELPR EGSSDVLVIK NEHVKKSDIW PSGGEMVVKD LTVKYMDDGN AVLENISFSI SPGQRVGLLG RTGSGKSTLL SAFLRMLNIK GDIEIDGVSW NSVTLQEWRK AFGVITQKVF IFSGTFRQNL DPNGKWKDEE IWKVADEVGL KSVIEQFPGQ LNFTLVDGGY VLSHGHKQLM CLARSVLSKA KIILLDEPSA HLDPITYQVI RRVLKQAFAG CTVILCEHRI EAMLDCQRFL VIEESNVWQY DSLQALLSEK SIFQQAISSS EKMRFFQGRH SSKHKPRTQI TALKEETEEE VQETRL
Kegg Pathway mmu02010:ABC transporters - Mus musculus (mouse)
mmu04971:Gastric acid secretion - Mus musculus (mouse)
mmu04972:Pancreatic secretion - Mus musculus (mouse)
mmu04976:Bile secretion - Mus musculus (mouse)
Disease Reference
KEGG disease -
Omim -
Drug Reference
Kegg drug
DrugBank -